In their article “Multimodal analysis of ocular inflammation using the endotoxin-induced uveitis mouse model,” Chu et al used images captured with the Phoenix OCT of the retina and anterior segment to correlate infiltrate level with neutrophil count during uveitis. To develop objective multimodal methods of analyzing infected eyes, they also examined flow cytometry of infiltrates,
13.03
2018
Micron IV Fundus Images Reveal Recapitulation of Phenotype in Retinal Dystrophy
Butterfly-shaped pigment dystrophy is an eye disease that produces butterfly-shaped lesions near the macula which can result in diminished visual acuity. In an article published in Nature Genetics, Saksens, Krebs, et al linked a mutation in the CTNNA1 gene to the disease in three families and found a mouse with the same mutation that showed a similar phenotype to the humans. The Micron IV rodent fundus camera revealed retinal dystrophy similar to humans.
19.02
2018
Surprising Preservation of Cone Function in Aged Alzheimer's-model Mice
Researchers at the University of Laval in Québec, Canada discovered unexpected findings with the Phoenix full field Ganzfeld electroretinography (ERG) system studying Alzheimer’s model mice. ERG assesses the function of the retinal cells including the photoreceptors, bipolar cells, and amacrine cells by flashing light at the retina and recording the electrical responses of the cells. By examining the height and speed of the electrical response wave forms, the retinal function integrity can be measured. The Phoenix Ganzfeld ERG system flashes green or UV light on the entire retina, which can tease out the function of rods, M-cones, and S-cones separately.
16.01
2018
Using the MICRON® IV to Study Light Induced Retinal Degeneration
Dr. Rafael Ufret-Vincenty’s lab at University of Texas Southwestern Medical Center has developed a novel model for light damage using the Micron IV rodent retinal imaging camera. This quick and consistent light damage model leads to fundus abnormalities and retinal thinning as measured by the Micron image-guided OCT and semi-automated layer analysis tool, Insight. In two elegant articles, the researchers provided proof of concept in pigmented mice, which are a better model for human eye light damage than overly sensitive albino mice, which demonstrated bleached fundus and outer retinal layer thinning.
06.12
2017
Retinal Ganglion Cell Survival During Chronic and Acute Injury
Using the Phoenix retinal imaging and functional measurement to study retinal ganglion cell survival during chronic (glaucoma) and acute (optic nerve crush) injury
Liu et al studied the survival and dysfunction of retinal ganglion cells (RGC) during chronic (glaucoma) and acute (optic nerve crush) injury in a series of comprehensive and elegant articles published from 2015 to 2017. The researchers used the Phoenix ERG and Micron IV provide a complete picture of RGC disruption.
02.11
2017
Micron Reveals Decreased Retinal Ganglion Cell Arborization in a Mouse Model of Retinal Ischemia
Researchers Dailey et al, in the Mitton Lab at Oakland University used the Micron retinal imaging camera to examine retinal ganglion cell (RGC) survival in a mouse model of retinal ischemia. Oxygen-induced retinopathy (OIR) in mice recapitulates critical factors of the human diseases retinopathy of prematurity and diabetic retinopathy. Mice pups were raised in hyperoxegenated air (75% oxygen) for five days and then returned to room air (20% oxygen), which lead to pathological changes in the vascular and neural growth.