Where do research ideas come from? Do they arrive in a thunderbolt eureka moment, or do they start as an observation or hunch, requiring some time to simmer, brew, incubate and grow? Some may evolve from an accidental or serendipitous discovery during a routine process. Observant operators of the Phoenix MICRON® retinal imaging system may
In their paper “Quantitative Analysis of Retinal Structure and Function in Two Chromosomally Altered Mouse Models of Down Syndrome”, researchers Victorino, Scott-McKean, et al leveraged the multi-modality capabilities of the Phoenix MICRON™ retinal imaging platform, to produce an image-rich research paper looking at the ocular features of Down Syndrome in two mouse models; Ts65Dn and
In their 2019 paper, “Novel molecular mechanisms for Prph2‐associated pattern dystrophy,” Chakraborty et al use the Phoenix MICRON® IV retinal imaging platform to longitudinally study the effect of a very specific mutation affecting the Peripherin 2 protein. Peripherin 2 is a protein in rods and cones which, if mutated, can lead to retinitis pigmentosa, cone-rod
In a recent well written, compelling article published in Nature Communications, “Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion,” Avrutsky et al show that caspase-9 inhibition is a promising treatment for retinal vein occlusion. Retinal vein occlusion models hypoxic-ischemic neurovascular damage and is the second leading cause of blindness in working-age adults.
A team of researchers at the Indian Institutes of Technology have published three detailed articles examining how to improve adeno-associated viruses (AAV). Maurya, S, Mary, B, Jayandharan, GR et al -approach the improvement of the viruses in a stunningly detailed gene-to-cell-to-whole-mouse model, narrowing down a multitude of options and producing impressive fluorescent fundus images and
Diabetic retinopathy is a crippling complication of diabetes that can lead to loss of vision, characterized by retinal inflammation, neurodegeneration, and disorganized microvascularization . Oxidative stress is crucial to the development of diabetic retinopathy. Iron is an essential micronutrient but, in excess, can become a highly damaging oxidative species. Excessive iron has been implicated in Parkinson’s