Researchers at Henan Province Eye Hospital in China have made great strides in studying endotoxin-induced uveitis (EIU) by creating a novel EIU model in zebrafish. Uveitis is an ocular inflammation and one of the main causes of visual impairment, accounting for 10-15% of global blindness. Mice have typically been the research animal of choice however
11.07
2023
Researchers find early signs of Alzheimer’s disease (AD) in the mouse retina and develop a non-invasive artificial intelligence-based system that could be used to diagnose the disease before the appearance of clinical symptoms
Progress in diagnosing and treating Alzheimer’s disease (AD) has been accelerating over the last few years. Until now, AD has been difficult to diagnose. The disease can be present years before distinguishable symptoms manifest. Non-invasive diagnostic tests have been lacking, and diagnosis often relies on memory, cognitive, and behavioral tests. In 2011, Koronyo-Hamaoui M, Koronyo
27.01
2021
Stunning fundus images of GFP-positive cells demonstrate new intravitreal injection technique
In their article, “A Novel Method Combining Vitreous Aspiration and Intravitreal AAV2/8 Injection Results in Retina-Wide Transduction in Adult Mice,” Da Costa et al use the Phoenix MICRON® III imaging platform to take stunning images demonstrating the success of their novel intravitreal injection technique. Gene therapy is a promising treatment option of genetic retinopathies—adeno-associated viruses
18.11
2020
The Phoenix MICRON® IV system and OCT help evaluate promising compounds for treatment of age-related macular degeneration
Age-related macular degeneration affects tens of millions of people worldwide, leading to vision impairment and blindness. Anti-VEGF treatment helps only 25-40% of patients, leaving others with no recourse to this progressive blinding disease. In their article, “Suppression of aberrant choroidal neovascularization through activation of the aryl hydrocarbon receptor,” Choudhary et al explore potential treatment using
27.03
2019
Phoenix MICRON® CNV System used to test a novel treatment for age-related macular degeneration
In their paper, “Suppression of Choroidal Neovascularization by AAV-Based Dual-Acting Antiangiogenic Gene Therapy,” Askou et al develop an adeno-associated virus (AAV) treatment for age-related macular degeneration. Beautiful fluorescent fundoscopy performed with the Phoenix MICRON® validated the success of the subretinal AAV injection, while precise choroidal neovascularization (CNV) induced by Phoenix laser burns confirmed that the
15.02
2019
Corneal Thickness Analysis using OCT
Corneal images taken with the Phoenix Micron IV OCT used for thickness analysis King et al, a consortium of researchers at a range of institutions, recently used the Phoenix Micron IV OCT to examine corneal thickness in their article, “Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing