For astronauts gazing out at the vastness of space, their eyes are not just windows to the cosmos but sensitive and vital instruments that must endure the challenging environment of life beyond Earth’s atmosphere. Although pressure suits, capsules, and space stations provide critical protection, astronauts are constantly exposed to extraterrestrial forces that impact various organ
10.07
2024
Tau Protein Modulation Impacts Retinal Neuron Survival in Glaucoma
Glaucoma, a leading cause of irreversible vision loss, is characterized by progressive damage to retinal ganglion cells (RGCs) and the optic nerve, often associated with increased intraocular pressure (IOP). While previous studies have implicated Tau protein expression and phosphorylation changes in other neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease and glaucoma, the causative role
28.02
2022
Analysis of imaging, structure and function using Phoenix MICRON™ modalities expand the understanding of ocular features of Down Syndrome in mouse models
In their paper “Quantitative Analysis of Retinal Structure and Function in Two Chromosomally Altered Mouse Models of Down Syndrome”, researchers Victorino, Scott-McKean, et al leveraged the multi-modality capabilities of the Phoenix MICRON™ retinal imaging platform, to produce an image-rich research paper looking at the ocular features of Down Syndrome in two mouse models; Ts65Dn and
30.01
2020
Measuring adeno-associated virus improvements with Phoenix MICRON® fluorescent imaging and Phoenix MICRON® Ganzfeld ERG
A team of researchers at the Indian Institutes of Technology have published three detailed articles examining how to improve adeno-associated viruses (AAV). Maurya, S, Mary, B, Jayandharan, GR et al -approach the improvement of the viruses in a stunningly detailed gene-to-cell-to-whole-mouse model, narrowing down a multitude of options and producing impressive fluorescent fundus images and
19.02
2018
Surprising Preservation of Cone Function in Aged Alzheimer's-model Mice
Researchers at the University of Laval in Québec, Canada discovered unexpected findings with the Phoenix full field Ganzfeld electroretinography (ERG) system studying Alzheimer’s model mice. ERG assesses the function of the retinal cells including the photoreceptors, bipolar cells, and amacrine cells by flashing light at the retina and recording the electrical responses of the cells. By examining the height and speed of the electrical response wave forms, the retinal function integrity can be measured. The Phoenix Ganzfeld ERG system flashes green or UV light on the entire retina, which can tease out the function of rods, M-cones, and S-cones separately.