Analyzing Choroidal Neovascularization (CNV) in pigs: Saline vs. Eylea™

The Micron X is a unique retinal imaging system optimized for eye research using large animals.  Micron X delivers brightfield images of pinpoint resolution and high contrast fluorescein angiograms.

Micron X Brightfield of Pig-Saline Control Group, 7 Day Post Laser and IVT Injection
Micron X Brightfield of Pig- Eylea™ Test Group, 7 day post laser and IVT Injection
Micron X Angiography of Pig-Saline Control Group, 7 Day Post Laser and IVT Injection
Micron X Angiography of Pig-Eylea™ Test Group, 7 day post laser and IVT Injection

In the experiment above, pigs received six laser shots per eye, with the control group receiving saline treatment and test group receiving Eylea™ treatment.  Eylea™, an FDA-approved drug, is an anti-vascular endothelial growth factor (anti-VEGF) that prevents vascular growth.  The crisp, high resoution brightfield and fluorescein angiography images, captured by the Micron X, show that Eylea™ clearly mitigates the neovascularization induced by laser burn.

The Micron X quickly and clearly acquired these images within minutes.

Experiments performed by Powered Research, LLC North Carolina, a preclinical CRO specializing in opthalmic models for life science R&D companies, utilizing a Phoenix Research Labs Micron X Large Animal Retinal Imaging Camera.

The Micron X is high power in a small, easily portable package. Hand and foot controls alter illumination and focusing. One objective lens will work with most large animal species, reducing costs and increasing versatility.