{"id":3820,"date":"2021-01-27T22:35:34","date_gmt":"2021-01-27T22:35:34","guid":{"rendered":"https:\/\/phoenixmicrdev.wpengine.com\/?p=3820"},"modified":"2026-04-02T17:50:42","modified_gmt":"2026-04-02T17:50:42","slug":"stunning-fundus-images-of-gfp-positive-cells-demonstrate-new-intravitreal-injection-technique","status":"publish","type":"post","link":"https:\/\/phoenixmicron.com\/fr\/stunning-fundus-images-of-gfp-positive-cells-demonstrate-new-intravitreal-injection-technique\/","title":{"rendered":"Stunning fundus images of GFP-positive cells demonstrate new intravitreal injection technique"},"content":{"rendered":"<p>In their article, \u201cA Novel Method Combining Vitreous Aspiration and Intravitreal AAV2\/8 Injection Results in Retina-Wide Transduction in Adult Mice,\u201d Da Costa et al use the Phoenix MICRON<span class=\"reg-mark half-size\">\u00ae<\/span> III imaging platform to take stunning images demonstrating the success of their novel intravitreal injection technique. Gene therapy is a promising treatment option of genetic retinopathies\u2014adeno-associated viruses (AAV) are already used to treat Leber\u2019s congenital amaurosis. Effective delivery of the AAV without causing further retinal disruption is essential. Da Costa et al found that by aspirating a small amount of the vitreous before intravitreally injecting their GFP-linked AAV, the transduction efficiency was vastly superior to the traditional intravitreal injection technique.<\/p>\n<figure id=\"attachment_3822\" aria-describedby=\"caption-attachment-3822\" style=\"width: 640px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"wp-image-3822 size-large lazyload\" data-src=\"https:\/\/phoenixmicron.com\/wp-content\/uploads\/2021\/01\/i1552-5783-57-13-5326-f01-e1611786119728-1024x389.png\" alt=\"Bright field and GFP-filter images\" width=\"640\" height=\"243\" data-srcset=\"https:\/\/phoenixmicron.com\/wp-content\/uploads\/2021\/01\/i1552-5783-57-13-5326-f01-e1611786119728-1024x389.png 1024w, https:\/\/phoenixmicron.com\/wp-content\/uploads\/2021\/01\/i1552-5783-57-13-5326-f01-e1611786119728-300x114.png 300w, https:\/\/phoenixmicron.com\/wp-content\/uploads\/2021\/01\/i1552-5783-57-13-5326-f01-e1611786119728-768x292.png 768w, https:\/\/phoenixmicron.com\/wp-content\/uploads\/2021\/01\/i1552-5783-57-13-5326-f01-e1611786119728-1536x584.png 1536w, https:\/\/phoenixmicron.com\/wp-content\/uploads\/2021\/01\/i1552-5783-57-13-5326-f01-e1611786119728.png 1929w\" data-sizes=\"(max-width: 640px) 100vw, 640px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 640px; --smush-placeholder-aspect-ratio: 640\/243;\" \/><figcaption id=\"caption-attachment-3822\" class=\"wp-caption-text\">Figure 1. The Phoenix MICRON<span class=\"reg-mark half-size\">\u00ae<\/span> III bright field (A-D) and GFP-filter (E-H) images show stunning GFP signal in eyes intravitreally injected with GFP-linked AAV2 without (B, C, F, G) or with (D, H) previous vitreous aspiration. A and E are control mice injected with PBS.<\/figcaption><\/figure>\n<p>Using the Phoenix MICRON<span class=\"reg-mark half-size\">\u00ae<\/span> III system to take fundus images in brightfield and with a GFP filter, Da Costa et al had four groups of mice with different injection techniques of a GFP-linked AAV2. The traditional intravitreal injection technique showed two to three spots of GFP-positive cells and some GFP around the optic nerve (Fig 1B, F). A second technique of making a small hole in the vitreous and applying pressure before injecting the AAV transduced a slightly larger area with GFP (Fig 1 C, G). The novel technique of aspirating some vitreous before injecting with the AAV showed a stunning expression of GFP all over the retina (Fig 1 D, H). As a control, mice injected with PBS using the novel technique did not have any GFP expression (Fig 1A, E).<br \/>\nDa Costa et al used the Phoenix MICRON<span class=\"reg-mark half-size\">\u00ae<\/span> OCT to confirm that the retina was not damaged by their novel injection technique\u2014there was some retinal detachment in a few mice that resolved after a week (Fig 2). The new aspirate and then inject technique may work for three reasons, Da Costa et al theorize: 1. The vitreous, if not aspirated, may exert pressure that forces the viral suspension out of the eye, 2. The internal limiting membrane is disrupted by the aspiration, allowing the viral particles to reach the retina, and 3. Aspirating the vitreous reduces the number of native neutralizing antibodies.<\/p>\n<p>This article is a wonderful demonstration of how the Phoenix MICRON<span class=\"reg-mark half-size\">\u00ae<\/span> III can be used to easily assess retinal treatment or techniques over a long period of time. The GFP-positive fundus images in this article are stunning.<\/p>\n<p><em>Citation: Da Costa, R., R\u00f6ger, C., Segelken, J., Barben, M., Grimm, C., &amp; Neidhardt, J. (2016). A Novel Method Combining Vitreous Aspiration and Intravitreal AAV2\/8 Injection Results in Retina-Wide Transduction in Adult Mice. Investigative Ophthalmology &amp; Visual Science, 57(13), 5326\u20135334.<\/em><\/p>\n<p><img decoding=\"async\" width=\"808\" height=\"437\" class=\"wp-image-3823 lazyload\" data-src=\"https:\/\/phoenixmicron.com\/wp-content\/uploads\/2021\/01\/FIg2.png\" alt=\"Figure 2. The Phoenix MICRON&lt;span class=\" data-srcset=\"https:\/\/phoenixmicron.com\/wp-content\/uploads\/2021\/01\/FIg2.png 808w, https:\/\/phoenixmicron.com\/wp-content\/uploads\/2021\/01\/FIg2-300x162.png 300w, https:\/\/phoenixmicron.com\/wp-content\/uploads\/2021\/01\/FIg2-768x415.png 768w\" data-sizes=\"(max-width: 808px) 100vw, 808px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 808px; --smush-placeholder-aspect-ratio: 808\/437;\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In their article, \u201cA Novel Method Combining Vitreous Aspiration and Intravitreal AAV2\/8 Injection Results in Retina-Wide Transduction in Adult Mice,\u201d Da Costa et al use the Phoenix MICRON\u00ae III imaging platform to take stunning images demonstrating the success of their novel intravitreal injection technique. Gene therapy is a promising treatment option of genetic retinopathies\u2014adeno-associated viruses [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":3822,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[22,35,1],"tags":[97,128,145,141,146,142,36,53,144,140,143],"class_list":["post-3820","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-micron-iv","category-oct","category-uncategorized","tag-adeno-associated-viruses","tag-fundus-image","tag-genetic-retinopathy","tag-gfp-linked-aav2","tag-gfp-positive","tag-intravitreal-injection","tag-oct","tag-optical-coherence-tomography","tag-retina-wide-transduction","tag-retinal-damage","tag-vitreous-aspiration"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Stunning fundus images of GFP-positive cells demonstrate new intravitreal injection technique - Phoenix-micron<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/phoenixmicron.com\/fr\/stunning-fundus-images-of-gfp-positive-cells-demonstrate-new-intravitreal-injection-technique\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Stunning fundus images of GFP-positive cells demonstrate new intravitreal injection technique - Phoenix-micron\" \/>\n<meta property=\"og:description\" content=\"In their article, \u201cA Novel Method Combining Vitreous Aspiration and Intravitreal AAV2\/8 Injection Results in Retina-Wide Transduction in Adult Mice,\u201d Da Costa et al use the Phoenix MICRON\u00ae III imaging platform to take stunning images demonstrating the success of their novel intravitreal injection technique. Gene therapy is a promising treatment option of genetic retinopathies\u2014adeno-associated viruses [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/phoenixmicron.com\/fr\/stunning-fundus-images-of-gfp-positive-cells-demonstrate-new-intravitreal-injection-technique\/\" \/>\n<meta property=\"og:site_name\" content=\"Phoenix-micron\" \/>\n<meta property=\"article:published_time\" content=\"2021-01-27T22:35:34+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-02T17:50:42+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/phoenixmicron.com\/wp-content\/uploads\/2021\/01\/i1552-5783-57-13-5326-f01-e1611786119728.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1929\" \/>\n\t<meta property=\"og:image:height\" content=\"733\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Phoenix-Micron Team\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"Phoenix-Micron Team\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/phoenixmicron.com\\\/fr\\\/stunning-fundus-images-of-gfp-positive-cells-demonstrate-new-intravitreal-injection-technique\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/phoenixmicron.com\\\/fr\\\/stunning-fundus-images-of-gfp-positive-cells-demonstrate-new-intravitreal-injection-technique\\\/\"},\"author\":{\"name\":\"Phoenix-Micron Team\",\"@id\":\"https:\\\/\\\/phoenixmicron.com\\\/fr\\\/#\\\/schema\\\/person\\\/cffed094aef7226545ce64624bd9b6fa\"},\"headline\":\"Stunning fundus images of GFP-positive cells demonstrate new intravitreal injection technique\",\"datePublished\":\"2021-01-27T22:35:34+00:00\",\"dateModified\":\"2026-04-02T17:50:42+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/phoenixmicron.com\\\/fr\\\/stunning-fundus-images-of-gfp-positive-cells-demonstrate-new-intravitreal-injection-technique\\\/\"},\"wordCount\":476,\"publisher\":{\"@id\":\"https:\\\/\\\/phoenixmicron.com\\\/fr\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/phoenixmicron.com\\\/fr\\\/stunning-fundus-images-of-gfp-positive-cells-demonstrate-new-intravitreal-injection-technique\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/phoenixmicron.com\\\/wp-content\\\/uploads\\\/2021\\\/01\\\/i1552-5783-57-13-5326-f01-e1611786119728.png\",\"keywords\":[\"adeno-associated viruses\",\"fundus image\",\"genetic retinopathy\",\"GFP-linked AAV2\",\"GFP-positive\",\"intravitreal injection\",\"OCT\",\"optical coherence tomography\",\"retina-wide transduction\",\"retinal damage\",\"vitreous aspiration\"],\"articleSection\":[\"Micron IV\",\"OCT\",\"Uncategorized\"],\"inLanguage\":\"fr-FR\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/phoenixmicron.com\\\/fr\\\/stunning-fundus-images-of-gfp-positive-cells-demonstrate-new-intravitreal-injection-technique\\\/\",\"url\":\"https:\\\/\\\/phoenixmicron.com\\\/fr\\\/stunning-fundus-images-of-gfp-positive-cells-demonstrate-new-intravitreal-injection-technique\\\/\",\"name\":\"Stunning fundus images of GFP-positive cells demonstrate new intravitreal injection technique - 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Les images Phoenix MICRON III en champ clair (A-D) et le filtre GFP (E-H) montrent un signal GFP \u00e9tourdissant dans les yeux inject\u00e9s par voie intravitr\u00e9enne avec l'AAV2 li\u00e9 \u00e0 la GFP sans (B, C, F, G) ou avec (D, H) aspiration vitr\u00e9enne pr\u00e9alable. A et E sont des souris t\u00e9moins auxquelles on a inject\u00e9 du PBS.\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/phoenixmicron.com\\\/fr\\\/stunning-fundus-images-of-gfp-positive-cells-demonstrate-new-intravitreal-injection-technique\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/phoenixmicron.com\\\/fr\\\/phoenix-micron\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Stunning fundus images of GFP-positive cells demonstrate new intravitreal injection technique\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/phoenixmicron.com\\\/fr\\\/#website\",\"url\":\"https:\\\/\\\/phoenixmicron.com\\\/fr\\\/\",\"name\":\"Phoenix-micron\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/phoenixmicron.com\\\/fr\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/phoenixmicron.com\\\/fr\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/phoenixmicron.com\\\/fr\\\/#organization\",\"name\":\"Phoenix-micron\",\"url\":\"https:\\\/\\\/phoenixmicron.com\\\/fr\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\\\/\\\/phoenixmicron.com\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/phoenixmicron.com\\\/wp-content\\\/uploads\\\/2019\\\/04\\\/faviconlogo.png\",\"contentUrl\":\"https:\\\/\\\/phoenixmicron.com\\\/wp-content\\\/uploads\\\/2019\\\/04\\\/faviconlogo.png\",\"width\":200,\"height\":200,\"caption\":\"Phoenix-micron\"},\"image\":{\"@id\":\"https:\\\/\\\/phoenixmicron.com\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/phoenixmicron.com\\\/fr\\\/#\\\/schema\\\/person\\\/cffed094aef7226545ce64624bd9b6fa\",\"name\":\"Phoenix-Micron Team\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/bf26b6ffbfc6145dcb9b0af2a88317a138f46f1cd51e55eab23daba4363203b2?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/bf26b6ffbfc6145dcb9b0af2a88317a138f46f1cd51e55eab23daba4363203b2?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/bf26b6ffbfc6145dcb9b0af2a88317a138f46f1cd51e55eab23daba4363203b2?s=96&d=mm&r=g\",\"caption\":\"Phoenix-Micron Team\"},\"url\":\"https:\\\/\\\/phoenixmicron.com\\\/fr\\\/author\\\/cvanhoverphoenixtechnologygroup-com\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Stunning fundus images of GFP-positive cells demonstrate new intravitreal injection technique - Phoenix-micron","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/phoenixmicron.com\/fr\/stunning-fundus-images-of-gfp-positive-cells-demonstrate-new-intravitreal-injection-technique\/","og_locale":"fr_FR","og_type":"article","og_title":"Stunning fundus images of GFP-positive cells demonstrate new intravitreal injection technique - Phoenix-micron","og_description":"In their article, \u201cA Novel Method Combining Vitreous Aspiration and Intravitreal AAV2\/8 Injection Results in Retina-Wide Transduction in Adult Mice,\u201d Da Costa et al use the Phoenix MICRON\u00ae III imaging platform to take stunning images demonstrating the success of their novel intravitreal injection technique. 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Les images Phoenix MICRON III en champ clair (A-D) et le filtre GFP (E-H) montrent un signal GFP \u00e9tourdissant dans les yeux inject\u00e9s par voie intravitr\u00e9enne avec l'AAV2 li\u00e9 \u00e0 la GFP sans (B, C, F, G) ou avec (D, H) aspiration vitr\u00e9enne pr\u00e9alable. 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