{"id":3498,"date":"2020-06-23T22:42:59","date_gmt":"2020-06-23T22:42:59","guid":{"rendered":"https:\/\/phoenixmicrdev.wpengine.com\/?p=3498"},"modified":"2026-04-02T17:50:43","modified_gmt":"2026-04-02T17:50:43","slug":"targeting-vegf164-in-muller-cells-may-be-useful-to-treat-retinopathy-of-prematurity","status":"publish","type":"post","link":"https:\/\/phoenixmicron.com\/es\/targeting-vegf164-in-muller-cells-may-be-useful-to-treat-retinopathy-of-prematurity\/","title":{"rendered":"Targeting VEGF<sub>164<\/sub> in M\u00fcller cells may be useful to treat retinopathy of prematurity"},"content":{"rendered":"<figure id=\"attachment_3499\" aria-describedby=\"caption-attachment-3499\" style=\"width: 300px\" class=\"wp-caption alignright\"><a href=\"https:\/\/phoenixmicron.com\/wp-content\/uploads\/2020\/06\/June-Figure-1.jpg\"><img decoding=\"async\" class=\"size-medium wp-image-3499 lazyload\" data-src=\"https:\/\/phoenixmicron.com\/wp-content\/uploads\/2020\/06\/June-Figure-1-300x175.jpg\" alt=\"Brightfield and GFP images of rats subretinally injected with PBS\" width=\"300\" height=\"175\" data-srcset=\"https:\/\/phoenixmicron.com\/wp-content\/uploads\/2020\/06\/June-Figure-1-300x175.jpg 300w, https:\/\/phoenixmicron.com\/wp-content\/uploads\/2020\/06\/June-Figure-1.jpg 548w\" data-sizes=\"(max-width: 300px) 100vw, 300px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 300px; --smush-placeholder-aspect-ratio: 300\/175;\" \/><\/a><figcaption id=\"caption-attachment-3499\" class=\"wp-caption-text\">Figure 1. Phoenix MICRON<span class=\"reg-mark half-size\">\u00ae<\/span> IV brightfield (top row) and GFP (bottom row) images of rats subretinally injected with PBS (e), a control virus (f), a virus knocking down VEGF (g), or a virus knocking down VEGF164 (h). Clear GFP expression allowed for identification of successful viral transfection and expression in-vivo.<\/figcaption><\/figure>\n<p>In Nature\u2019s Scientific Reports, Becker et al use the Phoenix MICRON<span class=\"reg-mark half-size\">\u00ae<\/span> IV, OCT, and focal ERG to assess the therapeutic value of knocking down a splice variant of VEGF in M\u00fcller cells in a model of Retinopathy of Prematurity (ROP). ROP is characterized by delayed vascularization of the retina after disrupted oxygen levels, followed by blood vessel growth into the intravitreal space, causing impaired vision and debilitating blindness Intravitreal anti-VEGF treats the vascularization but may also hurt delicate developing organs. Mouse studies using anti-VEGF treatment show smaller overall growth and reduced retinal capillary density as VEGF is important for both retina and organ development. A previous study targeting M\u00fcller cells with a short hairpin RNA against VEGF reduced intravitreal neovascularization without detrimental retina vascular effects, but also caused retinal thinning. The current study targeted the splice variant VEGF164 which is stimulated by oxygen fluctuations; mice without VEGF164 develop normally. The short hairpin lentivirus knocking down VEGF164 in M\u00fcller cells reduced intravitreal neovascularization and did not lead to retinal thinning.<\/p>\n<p><a href=\"https:\/\/phoenixmicron.com\/wp-content\/uploads\/2020\/06\/June-figure-2.png\"><img decoding=\"async\" width=\"300\" height=\"234\" class=\"size-medium wp-image-3505 lazyload\" data-src=\"https:\/\/phoenixmicron.com\/wp-content\/uploads\/2020\/06\/June-figure-2-300x234.png\" alt=\"MICRON&lt;span class=\" data-srcset=\"https:\/\/phoenixmicron.com\/wp-content\/uploads\/2020\/06\/June-figure-2-300x234.png 300w, https:\/\/phoenixmicron.com\/wp-content\/uploads\/2020\/06\/June-figure-2-1024x798.png 1024w, https:\/\/phoenixmicron.com\/wp-content\/uploads\/2020\/06\/June-figure-2-768x599.png 768w, https:\/\/phoenixmicron.com\/wp-content\/uploads\/2020\/06\/June-figure-2.png 1306w\" data-sizes=\"(max-width: 300px) 100vw, 300px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 300px; --smush-placeholder-aspect-ratio: 300\/234;\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<p>Rat pups were placed into a 10-50% oxygen cycling chamber for two weeks and then into room air to stimulate oxygen-induced retinopathy, a model of ROP. After one week in the oxygen-cycling chamber, one of three short hairpin lentiviruses with GFP targeting M\u00fcller cells was subretinally injected: one inert control, one VEGF knock down, and one VEGF164 knock down. The Phoenix MICRON<span class=\"reg-mark half-size\">\u00ae<\/span> IV was used to quickly identify successful expression of the virus in-vivo via GFP expression (Fig 1). The Phoenix MICRON<span class=\"reg-mark half-size\">\u00ae<\/span> OCT, which reveals the structure of the retina paired with live color video fundus, showed thinning of the photoreceptor and outer nuclear layers with knockdown of both VEGF and VEGF164, while the inner nuclear layer and the total retinal thickness unchanged. Insight 2D, a program included with the Phoenix MICRON<span class=\"reg-mark half-size\">\u00ae<\/span> OCT, allows for easy semi-automated segmentation and retinal thickness measurements shown in Figure 2. The Phoenix MICRON<span class=\"reg-mark half-size\">\u00ae<\/span> focal electroretinogram (ERG) allows for focal white light stimulus on a selected area of the retina. Using the focal ERG to measure the virus-expressing areas of the retina revealed no difference in function in the control, VEGF, or VEGF164 knockdown (Fig 3). While it is surprising that the VEGF knockdown did not harm retinal function, it may be because neuroprotective factors diffuse to the affected areas, and these were measured (Becker et al).<\/p>\n<figure id=\"attachment_3507\" aria-describedby=\"caption-attachment-3507\" style=\"width: 300px\" class=\"wp-caption alignright\"><a href=\"https:\/\/phoenixmicron.com\/wp-content\/uploads\/2020\/06\/June-figure-3.png\"><img decoding=\"async\" class=\"size-medium wp-image-3507 lazyload\" data-src=\"https:\/\/phoenixmicron.com\/wp-content\/uploads\/2020\/06\/June-figure-3-300x215.png\" alt=\"FigurPhoenix focal electroretinogram (ERG) charts\" width=\"300\" height=\"215\" data-srcset=\"https:\/\/phoenixmicron.com\/wp-content\/uploads\/2020\/06\/June-figure-3-300x215.png 300w, https:\/\/phoenixmicron.com\/wp-content\/uploads\/2020\/06\/June-figure-3-1024x735.png 1024w, https:\/\/phoenixmicron.com\/wp-content\/uploads\/2020\/06\/June-figure-3-768x551.png 768w, https:\/\/phoenixmicron.com\/wp-content\/uploads\/2020\/06\/June-figure-3.png 1332w\" data-sizes=\"(max-width: 300px) 100vw, 300px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 300px; --smush-placeholder-aspect-ratio: 300\/215;\" \/><\/a><figcaption id=\"caption-attachment-3507\" class=\"wp-caption-text\">Figure 3. The Phoenix focal electroretinogram (ERG) focally stimulates an area of the retina with white light. Example traces (a), and analysis showing no difference in a-wave (b) or b-wave (c) amplitude in animals treated with a control virus, a VEGF knock down virus, or a VEGF164 knock down virus.<\/figcaption><\/figure>\n<p>Using the Phoenix MICRON<span class=\"reg-mark half-size\">\u00ae<\/span> system to supplement immunohistochemistry and mRNA analysis, Becker et al concluded that selectively knocking down VEGF164 in M\u00fcller cells may have fewer deleterious effects than nonselective VEGFA inhibition in all retinal cells<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><em>Becker, S., Wang, H., Simmons, A. B., Suwanmanee, T., Stoddard, G. J., Kafri, T., &amp; Hartnett, M. E. (2018). Targeted Knockdown of Overexpressed VEGFA or VEGF164 in M\u00fcller cells maintains retinal function by triggering different signaling mechanisms. Scientific Reports, 8(1), 2003. <a href=\"https:\/\/doi.org\/10.1038\/s41598-018-20278-4\">https:\/\/doi.org\/10.1038\/s41598-018-20278-4<\/a><\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In Nature\u2019s Scientific Reports, Becker et al use the Phoenix MICRON\u00ae IV, OCT, and focal ERG to assess the therapeutic value of knocking down a splice variant of VEGF in M\u00fcller cells in a model of Retinopathy of Prematurity (ROP). ROP is characterized by delayed vascularization of the retina after disrupted oxygen levels, followed by [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[510,376,339,346,293],"tags":[521,522,410,524,526,515,519,517,513],"class_list":["post-3498","post","type-post","status-publish","format-standard","hentry","category-ferg","category-insight","category-mikron-iv","category-oct","category-nicht-kategorisiert","tag-anti-vegf","tag-elektroretinographie","tag-erg","tag-immunhistochemie","tag-mrna","tag-muellerzellen","tag-retinopathie-der-fruehgeburt","tag-rop","tag-vegf"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Targeting VEGF164 in M\u00fcller cells may be useful to treat retinopathy of prematurity - Phoenix-micron<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/phoenixmicron.com\/es\/targeting-vegf164-in-muller-cells-may-be-useful-to-treat-retinopathy-of-prematurity\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Targeting VEGF164 in M\u00fcller cells may be useful to treat retinopathy of prematurity - Phoenix-micron\" \/>\n<meta property=\"og:description\" content=\"In Nature\u2019s Scientific Reports, Becker et al use the Phoenix MICRON\u00ae IV, OCT, and focal ERG to assess the therapeutic value of knocking down a splice variant of VEGF in M\u00fcller cells in a model of Retinopathy of Prematurity (ROP). 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