{"id":2116,"date":"2019-02-15T19:43:30","date_gmt":"2019-02-15T19:43:30","guid":{"rendered":"http:\/\/www.phoenixreslabs.com\/?p=2116"},"modified":"2026-04-02T17:51:04","modified_gmt":"2026-04-02T17:51:04","slug":"corneal-thickness-oct","status":"publish","type":"post","link":"https:\/\/phoenixmicron.com\/es\/corneal-thickness-oct\/","title":{"rendered":"Corneal Thickness Analysis using OCT"},"content":{"rendered":"<p><strong>Corneal images taken with the Phoenix Micron IV OCT used for thickness analysis<\/strong><\/p>\n<p>King et al, a consortium of researchers at a range of institutions, recently used the Phoenix Micron IV OCT to examine corneal thickness in their article, \u201cGenomic locus modulating corneal thickness in the mouse identifies <em>POU6F2 <\/em>as a potential risk of developing glaucoma.\u201d Thinner central corneal thickness, which is hereditary, is associated with an increased risk of developing primary open angle glaucoma. While many genes are linked to central corneal thickness, they only explain 8% of variability. Using inbred mouse strains, King et al provide compelling evidence for linking the gene <em>Pou6f2<\/em> to central corneal thickness, potentially affecting glaucoma development, and even retinal ganglion cell loss during glaucoma.<\/p>\n<figure id=\"attachment_2117\" aria-describedby=\"caption-attachment-2117\" style=\"width: 580px\" class=\"wp-caption alignright\"><a href=\"https:\/\/phoenixmicron.com\/wp-content\/uploads\/2019\/02\/Corneal-OCT.png\"><img decoding=\"async\" class=\"wp-image-2117 size-blog-masonry-thumb lazyload\" data-src=\"https:\/\/phoenixmicron.com\/wp-content\/uploads\/2019\/02\/Corneal-OCT.png\" alt=\"\" width=\"580\" height=\"390\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 580px; --smush-placeholder-aspect-ratio: 580\/390;\" \/><\/a><figcaption id=\"caption-attachment-2117\" class=\"wp-caption-text\">Figure 1. OCT image of the cornea using the Phoenix Micron IV OCT. Measurement of the central corneal thickness is 115 \u00b5m in this mouse.<\/figcaption><\/figure>\n<p>BXI mice are a range of highly inbred substrains produced from the parent strains of C57BL\/6J and DBA2\/J and whose genomes have been fully mapped. King et al tested a total of 818 mice across 61 substrains of BXD. The Phoenix Micron IV OCT produced clear, crisp images of the cornea (Fig. 1). The included Insight semi-automated segmentation software allows for quantitative retinal and corneal segmentation. Using two OCT systems, including the Phoenix Micron IV OCT, the team found an average central corneal thickness of 100 \u00b5m across the BXD strains; the thinnest as 85 \u00b5m and the thickest was 125 \u00b5m (Fig. 2).<\/p>\n<figure id=\"attachment_2118\" aria-describedby=\"caption-attachment-2118\" style=\"width: 300px\" class=\"wp-caption alignleft\"><a href=\"https:\/\/phoenixmicron.com\/wp-content\/uploads\/2019\/02\/Mean-central-corneal-thickness-graph.png\"><img decoding=\"async\" class=\"size-medium wp-image-2118 lazyload\" data-src=\"https:\/\/phoenixmicron.com\/wp-content\/uploads\/2019\/02\/Mean-central-corneal-thickness-graph-300x148.png\" alt=\"\" width=\"300\" height=\"148\" data-srcset=\"https:\/\/phoenixmicron.com\/wp-content\/uploads\/2019\/02\/Mean-central-corneal-thickness-graph-300x148.png 300w, https:\/\/phoenixmicron.com\/wp-content\/uploads\/2019\/02\/Mean-central-corneal-thickness-graph-768x379.png 768w, https:\/\/phoenixmicron.com\/wp-content\/uploads\/2019\/02\/Mean-central-corneal-thickness-graph.png 776w\" data-sizes=\"(max-width: 300px) 100vw, 300px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 300px; --smush-placeholder-aspect-ratio: 300\/148;\" \/><\/a><figcaption id=\"caption-attachment-2118\" class=\"wp-caption-text\">Figure 2. The mean central corneal thickness of 61 BXD mouse strains measured using the Phoenix OCT.<\/figcaption><\/figure>\n<p>The BXD parent strains\u2019 average thickness is 93 \u00b5m for C57BL\/6J and 103 \u00b5m for DBA. The standard deviation of the central corneal thickness for each of the BXD substrains is small, indicating a strong hereditary component. Using genetic mapping tools, the researchers determined that <em>Pou6f2<\/em> may be a candidate for modulating central corneal thickness and thus changing risk for glaucoma and, intriguingly, retinal ganglion cell loss during glaucoma. The gene appears to be preserved in humans as well so may be a potential therapeutic target.<\/p>\n<p>While King et al used the retinal lens to image the cornea, Phoenix has a new anterior segment lens which produces detailed images of the cornea, lens, iris, and even Schlemm\u2019s canal.<\/p>\n<p>&nbsp;<\/p>\n<p><em>Reference: King R, Struebing FL, Li Y, et al. Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma.\u00a0PLoS Genet. 2018;14(1):e1007145. Published 2018 Jan 25. doi:10.1371\/journal.pgen.1007145<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Corneal images taken with the Phoenix Micron IV OCT used for thickness analysis King et al, a consortium of researchers at a range of institutions, recently used the Phoenix Micron IV OCT to examine corneal thickness in their article, \u201cGenomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[49,22,35,1],"tags":[57,25,58,36,42,59,60],"class_list":["post-2116","post","type-post","status-publish","format-standard","hentry","category-insight","category-micron-iv","category-oct","category-uncategorized","tag-corneal-thickness-analysis","tag-glaucoma","tag-mice-corneal-research","tag-oct","tag-phoenix-micron","tag-phoenix-micron-oct","tag-retinal-ganglion-cell-loss"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - 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